What are the best weight loss drugs, medicines, and supplements?

1. Prescription weight-loss drugs: Several types of prescription weight-loss drugs are available, including orlistat, lorcaserin, phentermine-topiramate, naltrexone-bupropion, and liraglutide. These medications are only available with a doctor's prescription and can help some people lose a significant amount of weight. 2. Over-the-counter diet pills: There are a variety of over-the-counter diet pills that claim to help with weight loss. However, the effectiveness of most of these products is limited and they may even be unsafe. 3. Supplements: Certain supplements, such as green tea extract, conjugated linoleic acid, and chromium picolinate, may help people lose weight when combined with a healthy diet and exercise. 4. Herbal remedies: Some herbal remedies, such as hoodia and bitter orange, are thought to help with weight loss. However, the safety and effectiveness of these remedies is not fully understood.